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12 04, 2019

Can HGH increase my height?

2019-04-26T12:23:34+08:00April 12th, 2019|Categories: blog|0 Comments

Do you have a question for Can HGH increase my height?

HGH, as its name suggests, is a human growth hormone which helps in a child’s growth vertically. Having optimum levels of this hormone is required for normal growth of a person. Genetic factors play a crucial role too. Yeh, HGH can increase your height

  • Human growth hormone supplements can increase an individual’s height up to five inches within many months by processing protein and increasing fat breakdown to help provide the energy needed for tissue growth.
  • The earlier the lack of growth hormone is treated in children, the better chance they have to grow to near-normal adult height.

Points to be noted:

  • HGH Human growth hormone (HGH) is an important hormone produced by your pituitary gland.
  • HGH helps your body with metabolism, cell repair and other vital functions.
  • Interestingly, diet and lifestyle choices can have a huge effect on our HGH levels.
  • If the body does not produce higher levels of this hormone then supplements are recommended.

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12 04, 2019

What is the effect of growth hormone on glycogenolysis?

2019-04-26T12:24:42+08:00April 12th, 2019|Categories: blog|0 Comments

Glycogenolysis is the biochemical breakdown of glycogen to glucose.

Glycogenesis is the formation of glycogen from glucose. From a pituitary clamp study, it came into understanding that the intake of HGH stimulates glucose production i.e. Glycogenolysis but has modest effects on liver glucose uptake, storage or utilization.

  • High dose GH infusion into healthy individuals increased glycogenolysis but had no effect on gluconeogenesis.
  • Sub-cutaneous injections of recombinant human GH in fasted nursing women for a week increased gluconeogenesis, but not glycogenolysis.

Where is Somatropin used?

12 04, 2019

What are the side effects of Somatropin?

2019-04-12T13:14:16+08:00April 12th, 2019|Categories: blog|0 Comments

Somatropin being one of the friendliest hormone supplements around does have some bad side effects when used in higher doses.

The side effects of a higher dosage of Somatropin are:

  • Can cause water retention around ankles and wrists
  • Carpal tunnel syndrome
  • Acromegaly (enlarged body parts)
  • Increased risk of heart attack
  • Hypoglycaemia and increased risk of diabetes
  • joint pain, headache, flu-like symptoms and back pain
  • Heightened cholesterol levels
  • Nerve irritation
  • Numbness
  • Possible abnormal organ growth
12 04, 2019

Where is Somatropin used?

2019-04-26T12:25:26+08:00April 12th, 2019|Categories: blog|0 Comments

Somatropin is a peptide and a synthetically generated HGH. This HGH can be used for numerous medical condition. Here is a list of the uses of somatropin.

  • The primary use is to help children suffering from growth disorders.
  • Can help adults who suffer from a human growth hormone deficiency.
  • HIV/AIDS patients can use it to maintain muscles
  • Used by Athletes and bodybuilders to gain a competitive edge
  • Brings about an improvement in skin appearance.
  • Relieves from depression in athletes
  • Better sleep and stronger bones

Can HGH increase my height?

7 03, 2019

What is TB-500?

2019-04-23T20:34:41+08:00March 7th, 2019|Categories: blog|Tags: |0 Comments

What is Thymosin Beta 4 TB-500

Thymosin Beta 4 is a naturally occurring peptide. Where to, Tb-500 is found in high concentrations in blood platelets, wound fluid and different tissues in the body. Thymosin Beta 4 is not a growth factor; rather, it is an important actin adjusting peptide.

Thymosin Beta 4 has been found to play a significant role in protection, regeneration, and remodeling of injured or damaged body tissues. The gene for TB-500 has also been found to be one of the first to be upregulated after a virus occurs.

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HOW TO USE Thymosin beta 4Tb-500

We suggested that this lyophilized vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. thymosin Beta 4 (TB-500).

Stock arrangements ought to be allotted into working aliquots and put away at <-2 degree. Further weakenings ought to be made in suitable cradled arrangements. Exploration has demonstrated that the best results are accomplished when utilizing clean saline arrangement (Sodium Chloride Injection BP 0.9%) to blend TB-500 (thymosin beta 4).

Important of TB-500 (Thymosin Beta 4):

Only prepare the vials that will be injected at once. If using doses that are less than the recommended dosage, prepared vials must be stored in the refrigerator and be used in side of 8 days.

TB-500 (Thymosin Beta 4) Vial preparation:

Get rid of the plastic top cap of the sealed vial containing the powder of peptides. Insert the filled syringe of 2ml of sodium chloride solution into the elastic top of the vial and transfuse the 2ml of sodium chloride into the vial.

Get off the syringe and lightly rotate the vial until the powder is completely dissolved. Ensure that the solution is well mixed with all powder thoroughly dissolved for maximum safety and effectiveness.

Frequency use for TB-500 (Thymosin Beta 4)

Examination considers having further shown that one (2mg. vial). each week for six continuous weeks obtains the best results. Thereafter, use only 10mg each month. It’s best to give the Sub-Q Inj. 6 days before intense workouts. Therefore for best results, 10mg injection per week for 6 continuous weeks, then 10mg per month (the glass vial is 2ml, with 2mg. of  TB-500 per vial), so it is 2mg/2ml)

Contraindications TB-500 (Thymosin Beta 4)

No known contraindications exist with other research peptides, however, there are not been thoroughly tested to know its full contraindications. Where to .The product should not be injected if the patient is pregnant or breastfeeding.

Storage for TB-500 (Thymosin Beta 4):

Lyophilized Thymosin beta 4 although stable valid at room temperature for 3 weeks, This lyophilized powder is stable at 2-8 degrees, but should be kept at -20 degrees for long term storage, preferably desiccated.

Upon reconstitution, the preparation is stable for up to one week at 2-8?. For maximal stability, apportion the reconstituted preparation into working aliquots and store at -20 to -70. Avoid repeated freeze/thaw cycles.

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7 03, 2019

What is Sermorelin Acetate?

2019-04-02T18:54:07+08:00March 7th, 2019|Categories: blog|Tags: |0 Comments

What is Sermorelin Acetate?

Sermorelin (GHRH) is a bio-identical hormone that has lately been genetically engineered to stimulate the excretion of Growth Hormone Releasing Hormone (GHRH) from the hypothalamus, a gland approach to the pituitary gland. GHRH is a peptide that is comprised of the first 29 amino acids of our own GH. These 29 amino acids are the active amino acids of GHRH. It is GHRH that stimulates the pituitary glands to liberate GH. As aging, the hormones created by the previous pituitary are exhausted. It has now been shown that GHRH can restore the GH-RNA to a youthful level causing elevation of levels of IGF-1.

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Product Name:Sermorelin 2mg
Catalogue Number:L648976
Synonyms:Sermorelin Acetate
CAS NO.:86168-78-7
Molecular Formula:C149H246N44O42S
Molecular Weight:3357.88
Source:Chemical Synthesis

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How does Sermorelin Acetate come?

Sermorelin is exhibited in a multi-dose, injectable vial. Every vial contains a powder plate which contains 2mg (2,000 micrograms) of lyophilized Sermorelin Acetate. The vial is vacuum sealed by the pharmacy for your protection and for the preservation of the hormone peptide.

How would I take Sermorelin Acetate ?

Sermorelin is injected into the body fat, subcutaneously, utilizing a little needle-like what a diabetic uses to infuse insulin. Injections are at first recommended for consistently and are diminished in recurrence after some time..

When do I take Sermorelin Acetate ?

The best time to take Sermorelin is before sleep time. Growth Hormone is primarily released during sleep and most beneficial to the body’s recovery and repair during this time. Sermorelin has a promoting effect on sleep and can therefore make you tired if taken during the day.

How do you measure the effectiveness of Sermorelin Acetate ?

Due to the pulsatile nature of both endogenous HGH and IGF-1, a single blood draw is not sufficient for accurate measurement. Most physicians who prescribe Sermorelin and similar peptides measure effectiveness in patients through symptomology (the study of your symptoms-see benefits); physical appearance and measurements; and more frequent blood analysis.

DOSAGE AND ADMINISTRATION for Sermorelin Acetate

A dose of 0.2 – 0.3 mg once every day at sleep time by subcutaneous infusion is prescribed. It is likewise suggested that subcutaneous infusion locales be intermittently pivoted. To anticipate conceivable defilement, wipe the elastic vial plug with a sterile arrangement before puncturing it with the needle. It is suggested that Sermorelin is controlled utilizing clean, expendable syringes and needles, The syringes ought to be of sufficiently little volume that the recommended measurement can be drawn from the vial with sensible accuracy.

To reconstitute Sermorelin, infuse the diluent into the vial of Sermorelin pointing the fluid against the glass vial divider. .Whirl the vial with a GENTLE rotational movement until substance are disintegrated totally. Try not to direct Sermorelin if particles are noticeable in the reconstituted arrangement or if the reconstituted arrangement is overcast.

SIDE EFFECTS for Sermorelin Acetate

A large proportion of patients develop anti- GRF antibodies at least once during treatment with Sermorelin. The significance of these antibodies is not clear and often a positive test at one growth assessment will become negative by the next assessment.

The presence of antibodies does not appear to affect growth or appear to be related to a specific adverse reaction profile.No generalized allergic reactions to Sermorelin have been reported.

The most common treatment-related adverse event (occurring in about 1 patient in 6) is a local injection reaction characterized by pain, swelling or redness. .Of 350 patients exposed to Sermorelin in clinical trials, three discontinued therapy due to injection reactions. Other treatment-related adverse events had individual occurrence rates of less than 1% and include headache, flushing, dysphagia, dizziness, hyperactivity, somnolence and urticaria.

When administered intravenously for diagnostic use, the following adverse reactions have been noted: flushing of the face, injection site pain, redness and/or swelling, nausea, headache, vomiting, dysgeusia, pallor, and tightness in the chest.

How will I know Sermorelin Acetate working?

After 4 years of observing patients taking Sermorelin, I have noticed that patients usually report improved sleep within the first few weeks of therapy. Of  course this is only noticed in patients who have trouble sleeping in the first place,however most patients at least notice an increase in sleep quality.This is usually concurrent with increased energy levels and improved mood.

After 3-6 months of therapy patients start reporting noticeable or significant body changes, such as increase in muscle tone and a leaner physique. .Over time patients will also notice a significant improvement in skin tone and health.

How long does Sermorelin Acetate take to work?

Just like most peptide hormones, Sermorelin usually has a loading period of 3-6 months before full effects are noticed. Once injected, both Sermorelin and rHGH are eliminated from the body very quickly and therefore need to be injected frequently.

Its actions are dependent on a chain reaction of biological processes which result in elevated and sustained HGH and growth factors. It takes some time for levels to become optimal and initiate the benefits we are seeking to achieve.

Do I need to take Sermorelin Acetate forever to keep seeing results?

Actually, no. Sermorelin has an ongoing effect in which optimal HGH levels can be sustained long after the last injection.Just like synthetic HGH, Sermorelin initially must be injected every day.

Unlike synthetic HGH,once optimal levels are sustained with Sermorelin injection frequencies can be decreased or stopped altogether..Once results are achieved,patients are then switched to a maintenance protocol eliminating the need for ongoing daily injections and reducing the total cost of therapy!

 Storage for  Sermorelin Acetate

Lyophilized SERMORELIN although stable at room temperature for 3 weeks,should be stored desiccated below -18°C..Upon reconstitution FST should be stored at 4°C between 2-7 days and for future use below -18°C

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7 03, 2019

What is PEG-MGF ?

2019-04-02T18:55:38+08:00March 7th, 2019|Categories: blog|Tags: |0 Comments

What is PEG-MGF (Pegylated Mechano Growth Factor)?

PEG-MGF (Pegylated Mechano Growth Factor) is a variant of IGF-1 (Insulin-like Growth Factor) which leads to an increase in the muscle cells necessary for adult muscles to continue growth beyond their genetic limit. Like other forms of IGF-1, PEG-MGF (also known as IGF-1ec) creates new muscle cells and stimulates muscle growth by promoting nitrogen retention and increasing protein synthesis.PEG-MGF differs from regular MGF as it has undergone a process of Pegylation which extends its half-life from less than 30 minutes to several days.

PEG-MGF for sale

Product Name:Peg-MGF
Catalogue Number:L463678
Synonyms:PEG-MGF,Mechano growth factor,IGF-1 EC
CAS NO. : 616204-22-9
Molecular Formula:C121H200N42039
Molecular Weight:2948.15
Source:Chemical Synthesis

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What is PEG-MGF (Pegylated Mechano Growth Factor)?

PEG-MGF (Pegylated Mechano Growth Factor) is a variant of IGF-1 (Insulin-like Growth Factor) which leads to an increase in the muscle cells necessary for adult muscles to continue growth beyond their genetic limit. Like other forms of IGF-1, PEG-MGF (also known as IGF-1ec) creates new muscle cells and stimulates muscle growth by promoting nitrogen retention and increasing protein synthesis.PEG-MGF differs from regular MGF as it has undergone a process of Pegylation which extends its half-life from less than 30 minutes to several days.

Pegylated Mechano Growth Factor (PEG-MGF) dosage

The average dose is 500 mcg per 24 hours; the frequency is 2-3 times per week. The drug is injected subcutaneously 1-2 hours before training to imitate physiologic secretion. The cycle duration is 5-6 weeks.

NOTE for Pegylated Mechano Growth Factor (PEG-MGF): 

Do not mix up all your vials at once. You should only mix up 1 (one) vial at a time and leave the rest in powder form until you are ready to use the next vial.
Running PEG MGF in synergy with IGF is perfect but there are things you need to know. If you lose them at the same time, as IGF has such strong receptor affinity, The effectiveness of MGF will just be wasted.

The best option and the very best choice I feel is this…IGF DES on workout days Pre-workout, or IGF1-LR3 this won’t blunt your body’s own MGF release from the liver, and whereas IGF1-LR3 has a more systematic effect and only a very small localized anabolic effect, DES, on the other hand, is very anabolic in a localized way, so bring up lagging muscle parts with DES, and then the following day Dose MGF at 200-400mcg subq to increase recovery and the mechanism for growth. Perfect synergy.

Over a 4 week run, I noticed about 4lb increase with the PEG MGF and DES partnership. And roughly the same weight in fat loss, very impressive, some though have noted far greater increases in muscle mass. If you’re on an AAS cycle there is no need for the addition of DES as IGF levels will already be elevated, then the addition of PEG MGF can take your recovery and gains to a new level.

HOW TO USE Pegylated Mechano Growth Factor (PEG-MGF)

This is a very important section. When using MGF that pegylated that the addition of Polyethylene glycol, it’s a nontoxic additive that increased the half-life of MGF from minutes to hours. This means its uses and versatility make it a tremendous addition to a bodybuilders arsenal. I have found it most effective as its effects are systematic, that means they have a whole body effect wherever muscle has been damaged or is diseased. The next aspect we need to look at is how to make the most use of a long-acting version of MGF.

When your muscle is damaged your body releases a pulse of an MGF splice variant as I outlined above, followed by a less anabolic longer-acting version from the liver… So it seems a waste to inject MGF at this time as you will just blunt your body’s own release, your not enhancing it. So using PEG MGF on nonworkout days is actually the very best route, the muscle has been damaged, so there are plenty of receptors for MGF, the effects are systematic so all muscles will be helped to recover through increased nitrogen retention, protein turnover, and satellite cell activation. Recovery is just going to skyrocket.

Doing this means your increasing the length of your body’s own mechanism for muscle repair and growth, your opening up the anabolic window.

Why PEGylated MGF is better

MGF exhibits local effects in skeletal muscle and without modification is not systemic(can’t travel through the body). The problem with synthetic MGF is that it is introduced IM and is water based so it goes into the bloodstream. MGF is not stable in the bloodstream for more than a matter of minutes. Biologically produced MGF is made locally and does not enter the bloodstream and is short acting so stability is not an issue. By PEGylating the MGF we can make synthetic MGF injected IM almost as efficient as local produced MGF.

Clinically proven Advanced Pegylation, the technology of polyethylene glycol (PEG) conjugation, holds significant promise in maintaining effective plasma concentrations of systemically administered drugs. It does this by surrounding part of the peptide with a unique structure made of polyethylene glycol, which can be attached to a protein molecule. The result of a correct PEGylation is similar to the protective mechanism of a turtle shell.

The polyethylene glycol groups protect the peptide but don’t surround it completely. The active sites of the peptide are still free to do their biological function. In this case, the shell is a negatively charged shield against positively charged compounds that would affect the protein. This also provides a nice steric chamber for the peptide to reside in. So it’s a happy turtle. Neurological research has shown that utilizing PEGylated MGF resulted in a longer more stable acting version of the MGF peptide in serum/blood.

Storage for PEGylated Mechano Growth Factor (PEG-MGF)

Dilute in STERILE WATER OR STERILE ACETIC ACID ONLY 1ml or 2mls per vial. If dilluted with STERILE WATER this peptide must be used within 7 to 10 days! If diluted with ACETIC ACID this peptide must be used within 21 days!

Vials are freeze-dried and therefore will remain stable at room temperature for 1-2 months. However, for long term storage, they should be kept a 2-8 degrees Celsius (refrigerator temperature), where they will remain stable for up to 18 months in powder form. Once mixed with the mixing solution, vials should be stored in the refrigerator and not left at room temperature.

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7 03, 2019

What is MGF research peptides?

2019-04-02T18:57:24+08:00March 7th, 2019|Categories: blog|Tags: |0 Comments

What is MGF- Mechano Growth Factor

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It adds stem cells into the muscle and is triggered by a pulse of stimulation after muscle tissues undergo significant mechanical stress. Genes for MGF are transcribed to a lesser degree as people age, which is why muscle mass decreases in the elderly, and certain diseases also interfere with the production of it. Supplements do not work as well for older people either because of the decrease in response to mechano growth factor.

Mechano growth factor (MGF) is a variation of muscle insulin-like growth factor-1 (IGF-1) triggered by rigorous exercise and muscle damage. Structurally different than other growth factors such as IGF-1 that is synthesized by the liver, MGF enters muscle fibers to repair skeletal muscle tissue and prevent damaged cells from dying off.

Product Name:MGF
Catalogue Number:L467890
Synonyms:Mechano Growth Factor,IGF-1Ec
CAS NO.: 108174-48-7
Molecular Formula:C121H200N42O39
Molecular Weight:2867.14
Sequence:H-Tyr-Gln-Pro-Pro-Ser-Thr-Asn-Lys-Asn-Thr-Lys-Ser-Gln-Arg-Arg-Lys-Gly-Ser-Thr-Phe-Glu-Glu-His-Lys-NH2
One Letter Sequence:YQPPSTNKNTKSQRRKGSTFEEHK-NH2
Source:Chemical Synthesis

What is the Difference Between mechano growth factor and IGF-1

The difference between mechano growth factor and IGF-1 is that a group of carbon molecules at the end of the protein, called a C-terminus, controls the release of signals that trigger secretion. When muscles are damaged, MGF is activated, triggers the formation of additional proteins, and enables healthy muscle cell nuclei to form into new tissues and muscle fibers. A more systemic type of insulin-like growth factor from the liver is also produced in higher quantities, aiding in the longer term repair process of muscles.

 Effects of MGF – Mechano Growth Factor

MGF is being used successfully by bodybuilders, for bringing up lagging body parts as well as overall growth. The most relevant rodent data has been shown that MGF is a very potent inducer of muscle growth when it is introduced into the muscle via an intramuscular injection of cDNA. In fact, in one study MGF caused a 20% increase in the weight of the injected muscle within 2 weeks. Further investigation elucidated that this was actually due to an increase in the size of the muscle fibers

Mechano Growth Factor (MGF) Dosage:

The recommended measure is 100-200mcg day by day. Peptide is best directed at least twice each day, bi-lateral dosages this will benefit to keep blood levels regular in your needed system, in cellular culture, or in vitro.

Why PEGylated MGF is better

MGF exhibits local effects in skeletal muscle and without modification is not systemic(can’t travel through the body). The problem with synthetic MGF is that it is introduced IM and is water based so it goes into the bloodstream. MGF is not stable in the bloodstream for more than a matter of minutes. Biologically produced MGF is made locally and does not enter the bloodstream and is short acting so stability is not an issue.

By PEGylating the MGF we can make synthetic MGF injected IM almost as efficient as local produced MGF. Clinically proven Advanced Pegylation, the technology of polyethylene glycol (PEG) conjugation, holds significant promise in maintaining effective plasma concentrations of systemically administered drugs. It does this by surrounding part of the peptide with a unique structure made of polyethylene glycol, which can be attached to a protein molecule. The result of a correct PEGylation is similar to the protective mechanism of a turtle shell.

The polyethylene glycol groups protect the peptide but don’t surround it completely. The active sites of the peptide are still free to do their biological function. In this case the shell is a negative charged shield against positively charged compounds that would affect the protein. This also provides a nice steric chamber for the peptide to reside in. So it’s a happy turtle. Neurological research has shown that utilizing PEGylated MGF resulted in a longer more stable acting version of the MGF peptide in serum/blood.

Bottom line
PEGylation can improve performance and dosing convenience of peptides, proteins, antibodies, oligonucleotides, and many small molecules by optimizing pharmacokinetics, increasing bioavailability, and decreasing immunogenicity and dosing frequency.PEGylation also can increase therapeutic efficacy by enabling increased drug concentration, improved biodistribution, and longer dwell time at the site of action. As a result, therapeutic drug concentrations can be achieved with less frequent dosing a significant benefit to patients who are taking injected drugs.

The PEG itself does not react in the body and is very safe. PEG has been approved by the US Food and Drug Administration (FDA) as a base or vehicle for use in foods and cosmetics and in injectable, topical, rectal and nasal pharmaceutical formulations. PEG has demonstrated little toxicity, is eliminated intact by the kidneys or in the feces and lacks immunogenicity. The risk associated with current PEGylated drugs is due to the way the drug itself acts not the PEG. MGF, as it is being currently sold, is getting a bad rep from people due to the fact they feel that they are not seeing gains from it.

Many people believe that the use of MGF in their cycles or protocols just flat out won’t work, however, this is far from the truth. Here it is plain and simple for you. Without any complex peptide understanding required other than the fact that PEGylation increases the stability, and lifetime of the peptide.MGF is responsible for increasing muscle stem cell count through a process called proliferation. As you see the effect going left to right here is exponential.

The more stem cells you have the more that can be stimulated and replicated. In order to signal this replication, there has to be sufficient saturation of cell receptors. Because attachment to a receptor is by simple probability, the more peptide and the more time the more probable a cell will reach saturation and begin to replicate.IF regular MGF has a shorter life span, it has a significantly smaller chance at saturating cells. It is not stable in the blood so its only real chance to bind is right at injection. If you calculate the probability of binding via (time x concentration) and then PEG last appx 300 times longer, the probability of MGF having a significant effect is about 300 times at the same dosage. In other words, you would need 300 times the regular MGF to bind to as many receptors as the PEGylated version. And even at that case the loss of peptide to the blood so fast would still limit the effects of MGF.

Now you must also consider the cumulative effects of having longer-term MGF action.AS you saw in the image, the number of receptors will increase, this increases the probability further for the PEG version so now every time you undergo muscle stem cell replication within the 4-8 days the PEG version is active you increase the probability proportional to the increase in cell number. So without knowing anything more than multiplication and the law of probability one can see that PEG MGF is significantly more effective.

Storage for Mechano Growth Factor (MGF):

Dilute in STERILE WATER OR STERILE ACETIC ACID ONLY 1ml or 2mls per vial. If diluted with STERILE WATER this peptide must be used within 7 to 10 days! If diluted with ACETIC ACID this peptide must be used within 21 days! Vials are freeze-dried and therefore will remain stable at room temperature for 1-2 months. However, for long term storage, they should be kept a 2-8 degrees Celsius (refrigerator temperature), where they will remain stable for up to 18 months in powder form. Once mixed with the mixing solution, vials should be stored in the refrigerator and not left at room temperature. 

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7 03, 2019

What usage is Melanotan 2 ?

2019-04-02T18:59:50+08:00March 7th, 2019|Categories: blog|0 Comments

What is Melanotan 2

Melanotan 2  is a cosmetic product that stimulates a natural increase in melanin production. Melanin is the main determinant of skin color in humans, a brown pigment which causes the skin to become darker in appearance, instead of red, when exposed to UV rays. Users of Melanotan 2 develop a gradual, natural looking tan with minimal sun exposure. It is particularly useful for fair-skinned individuals who find that they cannot tan simply by spending time in the sun; however, excellent cosmetic tanning results are achieved by all skin types.

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Melanotan II is not a treatment or cure for any disease, nor should it be used with the aim of preventing skin cancer. While melanin is known to have excellent photoprotectant properties, no clinical studies have ever indicated the efficiency of Melanotan II specifically in reducing UV damage, therefore the product should not be used solely as a replacement for sunscreen or other appropriate UV protection.

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I am very fair skinned; will Melanotan 2  work for me?

Melanotan II works for very well for all skin types and you can expect your tan to darken several shades regardless of how fair your skin is to begin with. Those with very pale skin have the most to gain from Melanotan 2 usage and usually end up seeing the most significant degree of change in their tan compared to those who have darker skin to begin with.

How many Melanotan 2  vials should I purchase to start with and when will I see results?

 

Generally, most people will see excellent results by the end of 20mg (2 vials) of Melanotan II, although some see results from as little as 5-10mg – which equates to being as quick as 7-10 days of beginning their injections. Those with extremely fair skin will need more Melanotan II to see initial results and most likely won’t see optimal results until 4-5 weeks of usage. The average time for great tanning results is 2-3 weeks assuming Melanotan 2 is combined with a sufficient amount of UV exposure.

Doses are weight dependent so those who weigh less (particularly women) can get away with purchasing less than those who are heavier. Your first Melanotan II vial will usually only last 2-3 weeks as daily injections are required. For maintenance (i.e. once you have a tan you are happy with), vials should last longer at 4-8 weeks depending on your dose.

 

What is the difference between Melanotan I & Melanotan 2 ?

Although they both stimulate the release of melanin, their purposes and mode of action are vastly different. Melanotan 1 (Afamelanotide) is being clinically trialed for its therapeutic benefits in the treatment of rare skin conditions. It is not used to cosmetic purposes as a dose of 6-8 times more would be needed to achieve similar tanning results to Melanotan II -a product used solely to assist cosmetic skin tanning results.


Comparing these two products would be similar to comparing a prescription stimulant medication such as Ritalin to a Red Bull drink. Both work as stimulants, but the prescription stimulant is used to treat medical conditions such as ADHD while Red Bull is a product used simply to assist in boosting energy.

 

How much Melanotan 2  do I need to take each time?

The dosing guideline for Melanotan II is 1mg per 100kg of bodyweight. Generally, for females, this equates to around 0.5-0.65mg of Melanotan II per injection (meaning 15-20 doses per vial) and for males 0.65mg-1mg per injection (10-15 doses per vial).

 

How often do I need to take Melanotan 2?

It is recommended to take your Melanotan II dose each day initially and go tanning 1-2 times a week if you wish to see results quickly (within 2-3 weeks). When you’re happy with your color you can cut back to injecting your dose to every 2nd or 3rd day and go tanning just once per week for maintenance. Basically the darker your skin becomes the less Melanotan 2 and UV rays you will need to maintain the tan.


 

Why do I still need to get UV exposure on Melanotan 2 ?

Clinical data indicates the tanning efficiency of Melanotan 2 without the need to combine it with any UV exposure, but results can be achieved much faster, and usually with a nicer overall color when you also incorporate 1-2 short tanning sessions per week with your Melanotan 2 usage.

The reason for this is that while Melanotan 2 does significantly raise levels of melanin in the body, UV rays play an important factor in the secretion of your body’s melanin into surrounding skin tissue -melanin is, of course, being the brown pigment responsible for giving your skin its tanned appearance.

 


 

How much water should I mix into the Melanotan 2 vial?

 

The amount of water you use makes no difference, it just means you will have 10mg of Melanotan 2 diluted in however much water you have used. For ease of dosing we recommend using just 1ml (100 units) of water. Therefore every 0.1ml (10 units) will be 1mg of Melanotan 2. 0.05ml (5 units) will be 0.5mg of Melanotan II etc.

 

How do I store Melanotan 2 ?

 

 

The manufacturer instructs that both mixed and unmixed vials of Melanotan II should be stored at refrigerator temperature at 2-8 degrees celcius. At this temperature mixed vials should be used within 2 months, while vials in powder form will remain stable for up to 1 year. To ensure no cross-contamination vials should always be stored away from food in an enclosed plastic satchel or container.

Are there any initial side effects for Melanotan 2 ?

 

 

For most users who take the appropriate dosage Melanotan II does not present any adverse side effects. Of those who do experience side effects they are generally those documented in the original clinical study of Melanotan 2 in humans, namely: flushing of the face, nausea and spontaneous erections in males. These side effects usually only last for 1-2 hours after the injection and usually only occur after the first 1-3 injections, after which they do not occur again unless a long break is taken between usage.

To reduce the occurrence of side effects its recommended to take your dose just before going to sleep at night and preferably having eaten 1-2 hours before (i.e. not on an empty stomach). If you are sensitive you should also take an anti-histamine 2 hours before injection.

 

Are there any long term side effects of Melanotan 2?

 

 

 

While Melanotan 2 was developed by scientists in the text. its usage in the general population is relatively new, with the earliest reports dating back to 2003. Unfortunately, it‘s impossible to know for certain the long term side effects of any product until it has been used by many individuals for a long period of time. Pleasingly though, reports and detailed logs from people using the product consistently for the past 5-6 years indicate that there are no documented long term side effects of Melanotan II usage.

This is not to say that we can guarantee the safety of Melanotan II, the information we present should not be mistaken as medical fact. As with any product (even licensed over the counter products), the safety and reaction of each individual cannot be 100% assured. So far though, no serious negative consequences have been reported by users. Furthermore, no hypothetical side effects or warnings reported in the media have been proven or substantiated with scientific fact – they are merely attempts not to get consumers to use an unlicensed product.

 

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7 03, 2019

Do you know Melanotan 1?

2019-04-02T19:01:16+08:00March 7th, 2019|Categories: blog|0 Comments

What is Melanotan 1  (MT-1)

Melanotan 1(Melanotan I,Afamelanotide, MT1)is an exact synthetic copy of a hormone found in the human body known as a-msh(alpha melanocyte stimulating hormone),which is responsible for increasing melanin. Melanin is the main determinant of skin color in humans,a brown pigment which causes skin to become darker in appearance,instead of red,when exposed to UV rays,also known as a “tan”.Compared to its closely related hormone “Melanotan II” it is weak and requires approximately 8-10 times the dosage to achieve the same results,however some prefer it due to its lower side effect profile when compared to Melanotan II.Melanotan I is a selective agonist of the MC1R (melanocortin 1 receptor) and does not have aphrodisiac effects.
Product Name:MELANOTAN-I 10mg/vial
Catalogue Number:L879809
Synonyms:MELANOTAN-I,MT1,Afamelanotide,melanotan I,melanotan
CAS NO.:75921-69-6
Molecular Formula:C78H111N21O19
Molecular Weight:1646.85
Amino acid Sequence:Ac-Ser-Tyr-Ser-Nle-Glu-His-D-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2
One Letter Sequence:Ac-SYS(Nle)EH(d-F)RWGKPV-NH2
Source:Chemical Synthesis

The Melanotan  1 Cycle

Melanotan 1 research peptidesWhere to buy Melanotan 1

Example- Skin type II, 180lb male
Day 1-2: .5mg each night
Day 3-6: 1mg when convenient
Day 7-10: 2mg when convenient
Day 11 on forward: begin dosing ~6mg/week
Day 7: 10min sun bed session. Cover face, use lotion, etc
Day 9: 10min sun bed session. Allow face some rays and obviously continue to use lotion liberally.
Day 11: 15min sun bed session

With peptides you are in control of your dose (as compared to having an implant controlling dosage).Allow a couple weeks before seeing UV exposure. Sunburn is to be avoided.

Fitzpatrick Skin Type Description
I Extremely fair skin, always burn, never tans.
II Fair skin, always burns, sometimes tans.
III Medium skin, sometimes burns, always tans.
IV Olive skin, rarely burns, always tans.
V Moderately pigmented brown skin, never burns, always tans.
VI Markedly pigmented black skin, never burns, always tans.

Dosing  for MT-1 (Melanotan 1) According to Skin Type

Fitzpatrick Skin Type I: 1mg-2mg/day. 100mg total may be necessary to achieve desired color. UV exposure after at least 20mg in system
Fitzpatrick Skin Type II: .75mg-1.5mg/day. 60mg should be sufficient to get color. UV exposure after 10-20mg
Fitzpatrick Skin Type III: .5mg-1mg/day. A sunless tan may be realistic here
Fitzpatrick Skin Type IV and beyond: Do not use Melanotan

Melanotan has a very brief half life (minutes). The melanin precursors and activated melanocytes last for months.
Missing a dose or taking time off is just fine. Intermittent therapy, lasting 10 days (skin type III) to 6 months (skin type I) is typical for researchers.

Melanotan can develop a protective tan in users. A natural tan is developed in response to cell damage caused by UV radiation. Ultraviolet rays penetrate the upper layers of the skin, triggering a-MSH, stimulating melanin production. Melanin deposits act as a natural sunblock at the cellular level. When melanin is oxidized by UV light it darkens, yielding a change in skin tone. Melanotan injections may offer a way to bring upon a safe, cosmetic tan with less damage.

Reconstituting for Melanotan 1 (MT-1)

Swab the stopper of both your MT-I vial and the vial of the dilutent (bacteriostatic water) with an alcohol swab.Take a syringe and draw up your bact water. The amount isn’t critical, other than making sure you know exactly how much you have used. The best rule of thumb is choose an amount that will make measuring the final product easy.

Example- 2ml(cc) per 20mg vial of MT-I would mean each 10 marks on a U100 insulin syringe would equal 1mg of Melanotan (MT-I)
Example- 1ml(cc) per 10mg vial of MT-I would mean each 10 marks on a U100 insulin syringe would equal 1mg of Melanotan (MT-I)

Avoid shooting the dilutent directly on the lyophilized powder. The powder should almost instantly dissolve. Gently swirl until the liquid is clear if powder did not dissolve upon contact.
Store your unused M-I in the refrigerator. Once reconstituted, the Melanotan should be good for 4-6 weeks in the refrigerator.

Melanotan 1 Measuring

After successfully reconstituting your peptide, now measure the desired amount out for injection. You will want to use a U100 insulin syringe to draw out your MT-I.
Since you know the amount of mg’s in your M-I vial, and you also know how much water you have diluted it with, we just divide this out as follows:
Note: 1ml = 1cc = 100 IU’s

So we take our number of mg’s of Melanotan and we divide that into the amount of dilutent we used.
Example- We used 2cc(ml) of water. We have a 20mg vial of MT-I.
From our formula above we know that 1cc = 100 IU’s, so we have 200 IU’s of water.
We now divide the 200 IU’s (the amount of our water) by 20mg (the amount of our M-I)
200 IU / 20mg = 10
This 10 will perfectly correspond with the markings on a U100 insulin syringe. In our example every 10 increments (1/10th of the syringe) on our syringe will equal 1mg of MT-I.

What is the difference between Melanotan 1 & Melanotan 2 ?

Although they both stimulate the release of melanin, their purposes and mode of action are vastly different. Melanotan I (Afamelanotide) is being clinically trialed for its therapeutic benefits in the treatment of rare skin conditions. It is not used to cosmetic purposes as a dose of 6-8 times more would be needed to achieve similar tanning results to Melanotan II -a product used solely to assist cosmetic skin tanning results.Comparing these two products would be similar to comparing a prescription stimulant medication such as Ritalin to a Red Bull drink. Both work as stimulants, but the prescription stimulant is used to treat medical conditions such as ADHD while Red Bull is a product used simply to assist in boosting energy.

Storage for Melanotan 1 (MT-1):

Vials are freeze-dried and therefore will remain stable at room temperature for 1-2 months. However, for long term storage they should be kept a 2-8 degrees celsius (refrigerator temperature), where they will remain stable for up to 18 months in powder form. Once mixed with mixing solution, vials should be stored in the refrigerator and not left at room temperature.

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