IGF-1 LR3

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IGF-1 LR3

$380.00 $325.00

Rated 4.63 out of 5 based on 8 customer ratings
(9 customer reviews)

Insulin-like growth factor-1 (IGF-1) is structurally similar to insulin. In fact, they are derived evolutionarily from the same precursor molecule, diverging at about 60 million years ago. These insulin-like factors function as metabolic signaling molecules that tell the body that basal nutritional needs have been met and there are enough resources for protein synthesis and cell proliferation

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Price $325.00 $315.25 $308.75 $299.00 $292.50

Description

Insulin-like growth factor-1 (IGF-1) is structurally similar to insulin. In fact, they are derived evolutionarily from the same precursor molecule, diverging at about 60 million years ago. These insulin-like factors function as metabolic signaling molecules that tell the body that basal nutritional needs have been met and there are enough resources for protein synthesis and cell proliferation. Consequentially, IGF-1 levels within the bloodstream are highly variable depending on nutrient uptake. A protein intake reduction of 25% can cause an equivalent reduction in IGF-1 plasma levels. In addition to nutritional regulation, growth hormone (GH) also regulates the synthesis of IGF-1 in the liver. However, adequate nutrition must be met in order for the liver to respond to GH stimulation. Upon stimulation of hepatocytes with GH, plasma levels of IGF-1 increase significantly, stimulating a negative feedback mechanism that signals the pituitary gland to suppress GH secretion. In the plasma IGF-1 binds 6 types of IGF binding proteins, effectively extending the half-life from 5 minutes to 16 hours. However, the interplay of the IGF-1 binding proteins and their regulation of free IGF-1 availability is not entirely understood. IGF-1 has very broad metabolic effects, stimulating growth of nearly all cell types. Essentially, upon binding to the IGF-1 receptor (IGF-1R) it tells the cell that adequate nutrition is available, avoid cell death, enhance protein synthesis, and proceed with cell division. In skeletal muscle, IGF-1 stimulates amino acid transport, enhances synthesis, and inhibits protein breakdown. IGF-1 Variants Currently, there are a few analogues that commercially available, differing in their potency and biodistribution. IGF-1 LR3 ( or LR3IGF-1) and IGF-1 DES( or Des1-3 IGF-1) have been shown to have increased potency, causing 3 to 5-fold increases in all growth and proliferative responses in rat models. The high potency of the LR3 analogue was achieved by incorporating a glutamine to arginine substitution at position 3 of the peptide. Similarly, IGF-1 DES is the result of a three amino acid truncation at the N-terminus of the peptide. In both analogues, these mutations effectively lower the binding of IGF-1 to the IGF-1 binding proteins and extended the half-life of the protein. As a result, IGF-1 no longer depends of the plasma proteins for an increased half-life and it is no longer under their complex regulation, making it free to hit IGF-1 receptors unhindered.
Synonyms: Long r3 IGF-1, LR3 IGF, IGF-1 LR3, Long Arg3 IGF-1
CAS: 946870-92-4
Molecular Formula: C990H1528N262O300S7
Molecular weight: 9200
Peptide purity: > 98.0%
Appearance: White powder
Related substance: Total Impurities(%) ≤ 2.0%
Acetate content: ≤ 15.0%
Bacterial Endotoxins: ≤2 EU/mg
Source:Chemical Synthesis
Reconstitution : As a general procedure, the manufacturer recommends reconstituting IGF-1 peptides in sterile, distilled water, with light sonication if necessary.
Storage: Although it is stable at room temperature for up to 3 weeks,lyophilized IGF-1 LR3 powder should be stored below -28°C. Upon reconstitution, IGF-1 LR3 solution should be stored at 4°C for less than 7 days and below -10°C for longer time. buy IGF-1 Lr3 online.Repeat Freeze-thaw cycles should be avoided for IGF-1 LR3 solution.

CAUTION:Any questions about IGF-1 LR3 peptide usage including,but not limited to bodybuilding, dosing, injections or cycling will be added to our DO NOT SELL LIST.This product is NOT intended to prevent, treat, or cure disease conditions or to affect the structure or function of the body. The sale of this product is restricted to research applications ONLY. This product is NOT for human consumption. This product can be harmful if ingested.

Additional information

Weight 0.08 kg
Dimensions 25 × 20 × 7 cm
Packing

1mg/vial, 10vials/kit

9 reviews for IGF-1 LR3

  1. Rated 4 out of 5

    Ramiro Wright

    Genuine product. Third transaction with this seller. Highly reliable and fast shipment

  2. Rated 4 out of 5

    Nicolas Andrews

    Good experience. Professional and kind staff. I recommend it.

  3. Rated 5 out of 5

    Rosemary Morton

    Amazing how clean and precise . Very happy . Look forward to next transaction.

  4. Rated 5 out of 5

    Trent Kaufman

    Great service, fast delivery!

  5. Rated 5 out of 5

    Raquel Drake

    The product is very good and I am satisfied with the quality. The sales manager Grace was very kind and professional. I am very pleased with the service and the professionalism of the company. I strongly recommend it.

  6. Rated 5 out of 5

    Ivan Montgomery

    Products with good quality and good service.

  7. Rated 5 out of 5

    Shyann Mccoy

    Super fast delivery, great customer service and a great product. A very easy transaction sent to me in Australia. 100% recommended.

  8. Rated 4 out of 5

    Talan Steele

    Excellent seller very fast right and I submit to all the world to buy her

  9. Rated 4 out of 5

    Laverne Rice

    Amazing how clean and precise . Very happy . Look forward to next trabssction

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